Graphene–DNAzyme junctions: a platform for direct metal ion detection with ultrahigh sensitivity† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c4sc03612c Click here for additional data file.
نویسندگان
چکیده
Many metal ions are present in biology and in the human body in trace amounts. Despite numerous efforts, metal sensors with ultrahigh sensitivity (< a few picomolar) are rarely achieved. Here, we describe a platform method that integrates a Cu2+-dependent DNAzyme into graphene-molecule junctions and its application for direct detection of paramagnetic Cu2+ with femtomolar sensitivity and high selectivity. Since DNAzymes specific for other metal ions can be obtained through in vitro selection, the method demonstrated here can be applied to the detection of a broad range of other metal ions.
منابع مشابه
Graphene–DNAzyme junctions: a platform for direct metal ion detection with ultrahigh sensitivity
Center for Nanochemistry, Beijing National Key Laboratory for Structural Chemistry of Chemistry and Molecular Engineering, Pe China. E-mail: [email protected] Department of Chemistry, University of Illinois 61801, USA. E-mail: [email protected] Adesso Advanced Materials Wuxi Co., Ltd., New District, Wuxi, Jiangsu Province, 21400 Department of Materials Science and Eng University, Beijing 100871, ...
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